Ganglion Cell Layer versus Retinal Nerve Fiber Layer Analysis for Detection of Retrograde Trans-Synaptic Degeneration

Segmental atrophy of the ganglion cell layer + inner plexiform layer complex thickness (GCL+IPLt) on spectral-domain optical coherence tomography (SD-OCT) has been demonstrated in vivo in cases of isolated post-geniculate visual pathway dysfunction, presumably through retrograde trans-synaptic degeneration (RTSD). Our goal with the present study was to investigate the differences in sensitivity and specificity between the analysis of the GCL+IPLt and the circumpapillary retinal nerve fiber layer thickness (RNFLt) on SD-OCT for the de novo recognition of RTSD.