Ganglion Cell Damage And Functional Recovery After Optic Neuritis

Optic neuritis (ON) is characterized by inflammation of the optic nerve and retrograde axonal and neuronal damage in the retina. In optical coherence tomography (OCT) the retinal nerve layer swells during the acute phase. In the post-acute phase RNFL and ganglion cell layer thin as a surrogate for axonal loss and neurodegeneration. During the acute phase, ON regularly leads to severe vision loss in the affected eye. Recovery from optic neuritis is defined as reconstitution of visual function after an acute ON. The objective was to describe ON recovery based on neuronal damage in the retina.