Evaluation of Pupil Response as Ocular Marker for Pre-Clinical Alzheimer's Disease

Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive deficits and visual dysfunction. There is increasing interest in the use of ocular markers as a surrogate for disease activity and progression in AD1. Several studies have shown that the pupillary light response (PLR ) can differentiate AD patients from healthy controls2,3 . However, the majority of these studies have assessed the PLR in subjects with established Alzheimer's disease, and it remains unclear whether the PLR is affected in subjects with pre-clinical AD.