The Injury Response Factor JUN is Expressed in Multiple Retinal Cell Types After Excitotoxic Insult

Excitotoxicity has been suggested to contribute to retinal ganglion cell (RGC) death in many diseases. The transcription JUN plays a major role in regulating RGC death after a variety of insults and has been shown to control excitotoxic neuronal death in other systems. Also, a recent study suggested that TNF released from Muller glial cells mediates excitotoxicity induced RGC death. Interestingly, JUN can control injury induced TNF expression. Therefore, JUN may play a central role in excitotoxicity induced RGC death.