Clinical Heidenhain Variant Of Sporadic Creutzfeldt-Jakob Disease (CJD) With Co-occurrence Of Prion Protein Types 1 and 2

Sporadic Creutzfeldt-Jacob disease (sCJD) is a rare neurodegenerative illness comprising five phenotypically distinct subtypes based on the methionine(M)/valine(V) polymorphism at codon 129 of the prion protein (PrP) gene and presence of either one of the two protease-resistant PrP (PrPres), referred to as PrPres type 1 and type 2.1, 2 The most common of these five subtypes includes the sCJDMM(MV)1 that matches the classic sCJD and comprises the \so-called Heidenhain variant (HsCJD) characterized by early and prominent visual symptoms.