Eosinophilic granulocyte (peripheral blood, human)

Electron microscopy. (A) Overview of the cell. Note two nuclear lobes (1) due to the section. There are numerous specific eosinophilic granules (2) and a Golgi area (3). Few thin filopodia (↓, arrows) are present. (B) Detail: some vesicles and many specific eosinophilic granules of varying sizes. These granules contain a central electron-dense angular or round crystalloid core (4) embedded in a finely granular matrix (5). The crystalloid consists of an alkaline protein called major basic protein (MBP); the matrix contains eosinophilic cationic protein (ECP), lysosomal enzymes such as eosinophil peroxidase for the production of hypochlorous or hypobromous acid, lactoferrin and hydrolases.