Resveratrol Nanoparticles Are Neuroprotective in Experimental, Optic Neuritis (Video)
Creator
Ehtesham Shamsher; Reas Khan; Kimberly Dine; Vy Luong; Benjamin Davis; Keirnan Willett; Satyanarayana Somavarapu; M. Francesca Cordeiro; Kenneth Shindler
Affiliation
(ES) University College London, London, United Kingdom of Great Britain and Northern Ireland; (RK) (KD) (KW) (KS) Scheie Eye Institute, University of Pennsylvania, Philadelphia; (BD) (MFC) Institute of Ophthalmology, University College London, London, United Kingdom of Great Britain and Northern Ireland; (SS) School of Pharmacy, University College London, London, United Kingdom of Great Britain and Northern Ireland
Optic neuritis is the most common clinical manifestation of multiple sclerosis. Axonal damage and neuronal loss lead to permanent neurological disability in patients and its animal model, experimental autoimmune encephalomyelitis (EAE). Presently, treatments of this condition aim to reduce inflammation without showing any neuroprotection. Resveratrol is a natural polyphenol found in red wine with neuroprotective effects but poor solubility in water. Thus, a novel nanoparticle formulation of resveratrol was developed and assessed in a mouse model of EAE.
Date
2020-03
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2020 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of
NANOS Annual Meeting 2020: Scientific Platform Session I
