| Identifier |
20240305_nanos_posters_265 |
| Title |
Adolescent Traumatic Optic Neuropathy: Recognizing a Role for Glia in Axon Injury Signaling Using a Murine Model of Brain Injury |
| Creator |
Shelby Hetzer; Nathan Evanson; Veeral Shah |
| Affiliation |
(SH) University of Cincinnati; (NE) (VS) Cincinnati Children's Hospital Medical Center |
| Subject |
Optic Nerve Trauma and Treatment; Optic Neuropathy; Pediatric Neuro-ophthalmology; Retina; Trauma |
| Description |
Traumatic brain injuries (TBI) comprise 1/3rd of all injury related deaths in the United States, with traumatic axonal injury (TAI) as one of the most devastating underlying pathologies. Traumatic optic neuropathy (TON) is a type of TAI that occurs with high incidence after TBI and can result in irreversible visual dysfunction. TON involves both oxidative and endoplasmic reticulum (ER) stress that is more severe in adolescent mice.1, 2 While secondary mechanisms of distal axon injury and somal responses are well studied (e.g., Wallerian degeneration3, 4), little is known about signaling between the axonal injury site and the soma.5 We hypothesize is that ER and OxStress influence each other in a reciprocal relationship that is unique to the proximal axon vs. the soma. |
| Date |
2024-03 |
| References |
1. Guilhaume-Correa, et al.; Greater neurodegeneration and behavioral deficits after single closed head traumatic brain injury in adolescent versus adult male mice, J Neurosci Res, 98(3), p. 557-570, 2020. 2. Torrens, Hetzer, and Evanson; Brief Oxygen Exposure after Traumatic Brain Injury Hastens Recovery and Promotes Adaptive Chronic Endoplasmic Reticulum Stress Responses, International Journal of Molecular Sciences, 24(12), p. 9831, 2023 3. Cheng and J.T. Povlishock; The Effect of Traumatic Brain Injury on the Visual System: A Morphologic Characterization of Reactive Axonal Change, Journal of Neurotrauma, 5(1), p. 47-60, 1988. 4. Carroll, Worley; Wallerian Degeneration, in Reference Module in Neuroscience and Biobehavioral Psychology, Elsevier, 2017 5. Roselli, Caroni; Life-or-death decisions upon axonal damage, Neuron, 73(3), p. 405-7,2012. |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2024 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2024: Poster Session: Analytical Studies: Disorders of the Anterior Visual Pathway (Retina, Optic Nerve, and Chiasm) |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2024. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6yx40p3 |
| Setname |
ehsl_novel_nam |
| ID |
2594098 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6yx40p3 |
