| Identifier |
20140304_nanos_posters_053 |
| Title |
Gap Junctions Propagate Melanopsin-like Responses Among Retinal Ganglion Cells in a Mouse Model of a Macular Degeneration |
| Creator |
Steven F. Stasheff; Frederick R. Blodi; Malini Shankar; Pratibha Singh; Robert F. Mullins; Michael P. Andrews; Edwin M. Stone; Stewart Thompson |
| Affiliation |
(SFS) Program in Neuroscience, University of Iowa & Carver College of Medicine, Iowa City, IA; (SFS) (FRB) (MS) (MPA) Department of Pediatrics, University of Iowa & Carver College of Medicine, Iowa City, IA; (SFS) (PS) (RFM) (EMS) (ST) Department of Ophthalmology & Visual Sciences and the Stephen A. Wynn Institute for Vision Research, University of Iowa & Carver College of Medicine, Iowa City, IA; (SFS) Department of Biomedical Engineering, University of Iowa & Carver College of Medicine Iowa City, IA |
| Subject |
Malattia Leventinese; Efemp1; Fibulin-3; R345W; Retinal Ganglion Cells |
| Description |
A missense mutation, R345W, in the extracellular matrix protein Efemp1 (or Fibulin-3) causes the autosomal dominant macular degenerative disease Malattia Leventinese (Stone et al. 1999). In mice with the same mutation, we previously discovered that about twice as many retinal ganglion cells as normal display melanopsin-like responses to light: long latency, sustained duration, and persistence when rod and cone photoreceptor input has been blocked pharmacologically (wild type: 45/354 [12.7%, SD = 7.0%]; Efemp1R345W: 109/449 [24.5%, SD = 4.3%] This study was designed to determine the origin of this physiological phenotype. |
| Date |
2014-03-04 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2014 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2014: Poster Presentations |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6fv1srx |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Setname |
ehsl_novel_nam |
| ID |
183880 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6fv1srx |
