Identifier |
20000329_nanos_pupilsympos_04 |
Title |
Aberrant Regeneration of the Pupil |
Creator |
Randy H. Kardon |
Affiliation |
University of Iowa, Iowa City, IA |
Subject |
Aberrant Regeneration; Pupil; Clinical Significance; Misdirection Syndromes |
Description |
Aberrant regeneration represents a misdirected growth of nerves to the iris dilator or sphincter (or their respective autonomic ganglion) following injury to both the axons and glial support tissue of the nerve. In response to the disruption of axons, the surrounding glial elements (Schwann cells) produce neurotropins (nerve growth factors). The result is profuse axonal sprouting from the surviving proximal nerve endings. The sprouting axons make their way through the disrupted glial support tissue or scar and become misdirected back into the wrong glial tubes. This is why the presence of aberrant regeneration almost always implies that damage to the nerve was from structural disruption due to trauma or compression (and not due to ischemia). As the misdirected axon sprouts continue their growth down the distal portion of the nerve they end up re-innervating the wrong target tissue. |
Date |
1999-03-18 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2000 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2000: Pupil |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2000. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6808861 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
182380 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6808861 |