Retinal Imaging by Scanning Laser Polarimetry (GDx-VCC) Corroborates OCT Evidence of Axonal Degeneration in Multiple Sclerosis

Optical coherence tomography (OCT) and scanning laser polarimetry with variable corneal compensation (GDx-VCC) show reduced retinal nerve fiber layer (RNFL) thickness in eyes with MS and other optic neuropathies. These techniques yield measurements that correlate with histology and are potentially useful in clinical trials, yet have important methodologic differences. We sought to compare the ability of GDx-VCC and OCT RNFL thickness to discriminate eyes of patients with MS vs. disease-free controls, to distinguish MS eyes with and without a past history of ON, and to correlate which scores for low-contrast letter acuity.