More than half a century ago, the phenomenon of transneuronal retrograde degeneration was shown convincingly at two levels of the monkey visual system: 1) within the inner nuclear layer of the retina, where cysts form after ganglion cell axon transection and 2) in the retinal ganglion cell layer, where neurons are lost after occipital lobe removal.
Date
2023-03
References
1. Van Buren JM. Trans-synaptic retrograde degeneration in the visual system of primates. J Neurol Neurosurg Psychiatry 1963;26:402-9. 2. Mehta JS, Plant GT. Optical coherence tomography (OCT) findings in congenital/long-standing homonymous hemianopia. Am J Ophthalmol 2005;140(4):727-9. 3. Jindahra P, Petrie A, Plant GT. Retrograde trans-synaptic retinal ganglion cell loss identified by optical coherence tomography. Brain 2009;132(Pt 3):628-34. 4. Gelfand JM, Nolan R, Schwartz DM, et al. Microcystic macular oedema in multiple sclerosis is associated with disease severity. Brain 2012;135(Pt 6):1786-93. 5. Ledda F, Paratcha G. Assembly of Neuronal Connectivity by Neurotrophic Factors and Leucine-Rich Repeat Proteins. Front Cell Neurosci 2016;10:199.
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2023 North American Neuro-Ophthalmology Society Annual Meeting