| Identifier |
20200309_nanos_sciplatform1_04 |
| Title |
Teprotumumab Effect on Proptosis, Diplopia and Quality of Life in Active Thyroid Eye Disease (TED) (Video) |
| Creator |
Jade Schiffman; Rosa Tang; George Kahaly; Terry Smith; Saba Sile; Elizabeth Thompson; Thomas Vescio; Jeffrey Sherman; Raymond Douglas |
| Affiliation |
(JS) (RT) Eye Wellness Center, Neuro-Eye Clinical Trials, Inc, Houston, Texas; (GK) Johannes Gutenberg University Medical Center, Mainz, Germany; (TS) University of Michigan Kellogg Eye Center, Ann Arbor, Michigan; (SS) (ET) (TV) (JS) Horizon Therapeutics plc, Lake Forest, Illinois; (RD) Cedars Sinai Medical Center, Los Angeles, California |
| Subject |
Graves (Systemic Disease), Neuro-ophth & Systemic Disease (eg. MS, MG, Thyroid), Optic Neuropathy, Adult Strabismus with a Focus on Diplopia, Orbit/Ocular Pathology |
| Description |
Active thyroid eye disease (TED), a progressive, autoimmune condition, produces retro-orbital inflammation/tissue expansion. Patients present with ocular pain, redness, and swelling. Retro-orbital fat/muscle expansion produces subsequent proptosis, diplopia, and strabismus. These manifestations can persist after inflammation is no longer evident. A phase 3 placebo-controlled trial recently confirmed that teprotumumab, an IGF-1R inhibitory antibody, significantly reduced TED-associated proptosis and improved other outcomes.[1] Key TED outcomes (proptosis [mm], subjective Bahn/Gorman diplopia grade, and GO-QOL) from the teprotumumab phase 2 and 3 trials are reported here.[1,2] |
| Date |
2020-03 |
| Language |
eng |
| Format |
video/mp4 |
| Type |
Image/MovingImage |
| Source |
2020 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2020: Scientific Platform Session I |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6kt21kv |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Setname |
ehsl_novel_nam |
| ID |
1541919 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kt21kv |
