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The Idiopathic Intracranial Hypertension Treatment Trial: Design Considerations and Methods

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Title Journal of Neuro-Ophthalmology, June 2014, Volume 34, Issue 2
Date 2014-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s63j6k3m
Setname ehsl_novel_jno
ID 227595
Reference URL https://collections.lib.utah.edu/ark:/87278/s63j6k3m

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Title The Idiopathic Intracranial Hypertension Treatment Trial: Design Considerations and Methods
Creator Friedman, Deborah I; McDermott, Michael P; Kieburtz, Karl; Kupersmith, Mark; Stoutenburg, Ann; Keltner, John L; Feldon, Steven E; Schron, Eleanor; Corbett, James J; Wall, Michael
Affiliation Departments of Neurology & Neurotherapeutics and Ophthalmology (DIF), University of Texas Southwestern Medical Center, Dallas, Texas; Departments of Ophthalmology, Neurology, Neurosurgery and Visual Science (SEF), Center for Human Experimental Therapeutics (KK, AS), Department of Biostatistics and Computational Biology and Department of Neurology (MM), University of Rochester School of Medicine and Dentistry, Rochester, New York; Neurology (MW), University of Iowa College of Medicine and Iowa City Veterans Affairs Health Care System, Iowa City, Iowa; National Eye Institute (ES), Bethesda, Maryland; Department of Ophthalmology and Vision Science (JK), University of California Davis Medical Center, Sacramento, California; Departments of Neurology and Ophthalmology (MK), Mount Sinai School of Medicine, New York, New York
Abstract The objectives of this study were to present the rationale for the main aspects of the study design and describe the trial methodology for the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). Eligible candidates with mild visual field loss (automated perimetric mean deviation [PMD] -2 to -7 dB) were randomized to receive either acetazolamide or matching placebo tablets. Randomized participants were offered participation in a supervised dietary program. The primary outcome variable, PMD, was measured at 6 months. Additionally, cerebrospinal fluid from subjects and serum from study participants and matched controls were collected for genetic analysis and vitamin A studies. An ancillary optical coherence substudy was added to investigate the changes of papilledema in the optic nerve head and retina that correlate with Frisn grading, visual field deficits, and low-contrast visual acuity.The randomized trial entered 165 participants from March 17, 2010, through November 27, 2012, from the United States and Canada. The primary outcome (month 6) visits were successfully completed by June 15, 2013. Blood specimens were obtained from 165 controls without IIH to investigate vitamin A metabolism and genetic markers of potential risk factors for IIH. The IIHTT is the first randomized, double-masked placebo-controlled trial to study the effectiveness of medical treatment for patients with IIH.
Subject Acetazolamide; Adolescent; Adult; Antihypertensive Agents; Cerebrospinal Fluid Pressure; Double-Blind Method; Female; Follow-Up Studies; Fundus Oculi; Humans; Male; Middle Older people; Perceptual Disorders; Pseudotumor Cerebri; Research Design; Retrospective Studies; Visual Field Tests; Visual Fields; Young Adult
OCR Text Show
Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227575
Reference URL https://collections.lib.utah.edu/ark:/87278/s63j6k3m/227575
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