Estrogen Induces IL-1β to Mediate Retinal Ganglion Cell Loss in Murine Optic Glioma

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Identifier 20230314_nanos_posters_226
Title Estrogen Induces IL-1β to Mediate Retinal Ganglion Cell Loss in Murine Optic Glioma
Creator Yunshuo Tang; Jit Chatterjee; Ngan Wagoner; David Gutmann
Affiliation (YT) (JC) (NW) (DG) Washington University in Saint Louis
Subject Tumors; Optic Neuropathy; Pediatric Neuro-ophthalmology; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid)
Description Optic pathway glioma (OPG) is a low-grade astrocytoma seen in 15-20% of children with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome. While not fatal, 30-50% of children with NF1-OPG exhibit retinal ganglion cell (RGC) death and vision loss, which is three times more frequent in girls. Using murine Nf1-OPG models, we previously demonstrated that estrogen acts at the level of microglia to induce RGC death. Herein, we present evidence that estrogen mediates RGC death through IL-1β.
Date 2023-03-14
Language eng
Format application/pdf
Type Text
Source 2023 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of NANOS Annual Meeting 2023: Poster Session II: Disorders of the Anterior Visual Pathway (Retina, Optic Nerve, and Chiasm)
Collection Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6q1ty92
Setname ehsl_novel_nam
ID 2335431
Reference URL https://collections.lib.utah.edu/ark:/87278/s6q1ty92
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