Intracranial Hypertension in Transgender Patients

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Title Intracranial Hypertension in Transgender Patients
Creator Eric Weinlander; Talal Derani; Wayne T. Cornblath; Lindsey B. De Lott
Affiliation Department of Ophthalmology and Visual Sciences, W.K. Kellogg Eye Center, University of Michigan, Ann Arbor, Michigan
Abstract Idiopathic intracranial hypertension (IIH) is a potentially blinding condition characterized by increased intracranial pressure, papilledema, headaches, and vision loss (1). The role of exogenous sex hormones in the development of IIH is controversial (2). Five cases of IIH occurring in transgender patients undergoing female-to-male (FTM) transition with exogenous testosterone have been reported, suggestive of a causal relationship between exogenous testosterone use and IIH (3). In 3 of the 5 patients, exogenous testosterone was altered or discontinued. We report 2 additional cases in transgender patients: one in a patient undergoing FTM transition and the other in a patient undergoing male-to-female (MTF) transition. In both, the manifestations of intracranial hypertension were managed entirely without any modification of the patient's hormonal therapies, demonstrating that gender-affirming hormonal therapy can be safely continued in transgender patients with IIH.
Subject Acetazolamide / therapeutic use; Adult; Carbonic Anhydrase Inhibitors / therapeutic use; Delayed-Action Preparations; Estradiol / administration & dosage; Female; Humans; Intracranial Hypertension / diagnosis; Intracranial Hypertension / drug therapy; Male; Testosterone / administration & dosage; Transgender Persons; Transsexualism
OCR Text Show
Date 2019-06
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, June 2019, Volume 39, Issue 2
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6gb7tj2
Setname ehsl_novel_jno
ID 1595870
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gb7tj2
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