Chronic Progressive External Ophthalmoplegia in the Absence of Ptosis

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Title Chronic Progressive External Ophthalmoplegia in the Absence of Ptosis
Creator Robert C. Bucelli, MD, PhD; Michael S. Lee, MD; Collin M. McClelland, MD
Affiliation Department of Neurology (RB), Washington University School of Medicine, St. Louis, Missouri; and Departments of Ophthalmology and Visual Neurosciences (ML, CMM), Neurology (ML), and Neurosurgery (ML), University of Minnesota, Minneapolis, Minnesota
Abstract Idiopathic intracranial hypertension (IIH) is a well-characterized syndrome, most commonly affecting obese women of childbearing age. Differences in its prevalence have been reported in various populations. The aim of this article was to determine whether differences in clinical presentation and management exist for patients with IIH between different regions the world.; ; Retrospective database analysis of adult patients with IIH from 4 different neuro-ophthalmology clinics. The data collected included gender, age of onset, body mass index (BMI), lumbar puncture opening pressure, initial visual acuity (VA), initial visual field (VF) mean deviation (MD), pharmacological or surgical treatment, length of follow-up, final VA, and final VF MD.; ; The study population consisted of 244 patients, with significant regional variations of female to male ratio. Overall, there was no significant difference regarding the age of diagnosis or the BMI. Acetazolamide was the first line of treatment in all groups but there was a difference between countries regarding second-line treatment, including the use of surgical interventions. Mean initial VA differed between groups but the final change in VA was the same among all the study groups.; ; There are differences in IIH presentation, treatment, and response to therapy among different countries. International prospective studies involving multiple centers are needed to determine the potential influence of environmental and genetic factors on the development of IIH and to improve the management of this potentially blinding disorder.
Subject Case-Control Studies; Cornea; Corneal Topography; Cross-Sectional Studies; Elasticity; Female; Follow-Up Studies; Humans; Intraocular Pressure; Male; Middle Older people; Optic Nerve; Optic Neuropathy, Ischemic; Prospective Studies; Sclera; Tonometry, Ocular; Visual Acuity
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Date 2016-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, September 2016, Volume 36, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s61s0k17
Setname ehsl_novel_jno
ID 1276522
Reference URL https://collections.lib.utah.edu/ark:/87278/s61s0k17
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