Pregnancies complicated by antiphospholipid antibodies: effect of prednisone on the activated partial thromboplastin time and antiphospholipid antibody levels.

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Title Pregnancies complicated by antiphospholipid antibodies: effect of prednisone on the activated partial thromboplastin time and antiphospholipid antibody levels.
Publication Type thesis
School or College School of Medicine
Department Pathology
Author Li-Rommel, Yin.
Date 1987-08
Description Lupus anticoagulant is an anti-phospholipid autoantibody which is associated with several adverse pregnancy outcomes including recurrent pregnancy loss, intrauterine fetal death, and intrauterine growth retardation. Treatment of the mother during pregnancy with prednisone and low-dose aspirin increases the rate of delivering a viable infant. Furthermore, successful outcome has been associated with "correction" of the prolonged partial thromboplastin time by prednisone. I studied the effect of prednisone therapy (40-120 mg per day) on the partial thromboplastin time and anti-phospholipid antibody levels in eight pregnant women with lupus anticoagulant and correlated the observed changes with the pregnancy outcome. In all cases, the partial thromboplastin time declined during the treatment. Restoration of the partial thromboplastin time to the normal range was shown in six patients, of whom three had living infants and three had pregnancy losses. The anti-phospholipid antibodies were detected by an enzyme-linked immunoabsorbant assay. In two of five patients who had living infants, the antibody levels returned to normal range at the end of treatment, but the remained abnormal in three others as well as in three patients with pregnancy losses. This study demonstrates that although treatment with prednisone increases the successful pregnancy outcome of patients with lupus anticoagulant, the effect of the regimen on the partial thromboplastin time doe not predict the pregnancy outcome. The effect of prednisone on anti-phospholipid antibody levels is unpredictable and it is difficult to predict the therapeutic efficacy be determining the antibody levels.
Type Text
Publisher University of Utah
Subject Prednisone; Pregnancy Complications
Subject MESH Autoimmune Diseases; Autoantibodies
Dissertation Institution University of Utah
Dissertation Name MS
Language eng
Relation is Version of Digital reproduction of "Pregnancies complicated by antiphospholipid antibodies: effect of prednisone on the activated partial thromboplastin time and antiphospholipid antibody level." Spencer S. Eccles Health Sciences Library. Print version of "Pregnancies complicated by antiphospholipid antibodies: effect of prednisone on the activated partial thromboplastin time and antiphospholipid antibody level." available at J. Willard Marriott Library Special Collection. RC 39.5 1987 L5.
Rights Management © Ying Li-Rommel.
Format application/pdf
Format Medium application/pdf
Identifier us-etd2,48
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
ARK ark:/87278/s6m620tp
Setname ir_etd
ID 192591
Reference URL https://collections.lib.utah.edu/ark:/87278/s6m620tp
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