Endogenous Flavoprotein Fluorescence Imaging Revealed Increased Metabolic Stress in Nonarteritic Anterior Ischemic Optic Neuropathy
| Identifier | 20230314_nanos_posters_336 |
| Title | Endogenous Flavoprotein Fluorescence Imaging Revealed Increased Metabolic Stress in Nonarteritic Anterior Ischemic Optic Neuropathy |
| Creator | Sangeethabalasri Pugazhendhi; Miaomiao Yu; Ping Zhu; Collin Rich; Yaping Joyce Liao |
| Affiliation | (SP) (MY) (PZ) (YJL) Stanford University; (CR) OcuSciences, Inc. |
| Subject | Optic Neuropathy; Neuroimaging; Stroke; Miscellaneous |
| Description | Endogenous flavoprotein fluorescence (FPF) imaging is an emerging functional assessment of optic neuropathies and retinopathies. An increase in FPF indicates oxidative stress in vivo due to increased blue light absorption and green light emission that reflect accumulation of oxidized flavoprotein. Mitochondrial stress is a key pathogenic mechanism for multiple optic neuropathies, including non-arteritic anterior ischemic optic neuropathy (NAION), the most common acute optic neuropathy in adults over 50 years of age. In this study, we performed FPF imaging in patients with unilateral and bilateral NAION and investigated whether metabolic stress correlates with severity of disease. |
| Date | 2023-03-14 |
| References | 1. Zhou, Castanos, Geyman, Rich, Tantraworasin et al. Mitochondrial Dysfunction in Primary Open- Angle Glaucoma Characterized by Flavoprotein Fluorescence at the Optic Nerve Head, Ophthalmol Glaucoma, 5, 413-420, 2022. 2. Chen, Conti, Hom, Greenlee, Raimondi, et al., Functional imaging of mitochondria in retinal diseases using flavoprotein fluorescence, Nature Eye, 35, 74-92, 2020. 3. Elner SG, Elner VM, Field, Park, Heckenlively, et al., Retinal flavoprotein autofluorescence as a measure of retinal health, Trans Am Ophthalmol Soc, 106, 215-224, 2008. 4. Sanz-Morello, Ahmadi, Vohra, Saruhanian, Freude, et al., Oxidative Stress in Optic Neuropathies, Antioxidants, 10, 1538, 2021. 5. Osborne, Pathogenesis of ganglion "cell death" in glaucoma and neuroprotection: focus on ganglion cell axonal mitochondria, Progress in Brain Research, 173, 339-352, 2008. |
| Language | eng |
| Format | application/pdf |
| Type | Text |
| Source | 2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of | NANOS Annual Meeting 2023: Poster Session II: Ocular-Imaging |
| Collection | Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher | Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution | North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management | Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK | ark:/87278/s6twcykw |
| Setname | ehsl_novel_nam |
| ID | 2335541 |
| Reference URL | https://collections.lib.utah.edu/ark:/87278/s6twcykw |