Foreign body response to central nervous system implants

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Title Foreign body response to central nervous system implants
Publication Type dissertation
School or College College of Engineering
Department Biomedical Engineering
Author Winslow, Brent Donald
Date 2010-12
Description Implanted biomedical devices play an important role in the treatment of central nervous system diseases and disorders, but are also subject to a foreign body response which has the potential to affect device function. For example, the recordings obtained from the cerebral cortex using penetrating microelectrode arrays have been shown to be sufficient in limited clinical trials to control computers or external devices in the field of neuroprosthetics, but such recordings are largely inconsistent in chronic applications. Following implantation, a local area of inflammation develops surrounding the implant, which consists of activated microglia/macrophages, astrocyte hypertrophy, and neuronal loss, and which appears to last for the lifetime of the implant. The focus of this dissertation was to investigate the local tissue response in rat cerebral cortex adjacent to microwires, silicon microelectrodes with different surface chemistries, and microelectrode designs with decreased surface area available for inflammatory cell attachment.
Type Text
Publisher University of Utah
Subject Electrode; Foreign body response; Inflammation; Neural prosthesis; Neurogenesis
Subject LCSH Implants, Artificial; Central nervous system -- Surgery; Foreign-body reaction
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Rights Management © Brent Donald Winslow
Format application/pdf
Format Medium application/pdf
Source Original in Marriott Library Special Collections, RD14.5 2010 .W56
ARK ark:/87278/s6j3978d
Setname ir_etd
ID 194184
Reference URL https://collections.lib.utah.edu/ark:/87278/s6j3978d
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