Pathology of the Brain and the Eye in Severe Acute Respiratory Syndrome Coronavirus-2-Infected Patients: A Review

Update Item Information
Title Pathology of the Brain and the Eye in Severe Acute Respiratory Syndrome Coronavirus-2-Infected Patients: A Review
Creator Samantha N. Champion; Imani M. Williams; Maria Martinez Lage; Anna M. Stagner
Affiliation C.S. Kubik Laboratory for Neuropathology (SNC, MML), Massachusetts General Hospital, Boston, Massachusetts; David G. Cogan Ophthalmic Pathology Laboratory (IMW, AMS), Massachusetts Eye and Ear Infirmary, Boston, Massachusetts; and Department of Pathology (SNC, MML, AMS), Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
Abstract Background: Patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may present or eventually develop central nervous system and ophthalmic signs and symptoms. Varying reports have emerged regarding isolation of viral RNA from these tissue sites, as well as largely autopsy-based histopathologic descriptions of the brain and the eye in patients with COVID-19. Evidence acquisition: A primary literature search was performed in literature databases such as PubMed, Google Scholar, and Cochrane Library. Keywords were used alone and in combination including the following: SARS CoV-2, COVID-19, eye, brain, central nervous system, histopathology, autopsy, ocular pathology, aqueous, tears, vitreous, neuropathology, and encephalitis. Results: The reported ophthalmic pathologic and neuropathologic findings in patients with SARS-CoV-2 are varied and inconclusive regarding the role of direct viral infection vs secondary pathology. The authors own experience with autopsy neuropathology in COVID-19 patients is also described. There is a particular paucity of data regarding the histopathology of the eye. However, it is likely that the ocular surface is a potential site for inoculation and the tears a source of spread of viral particles. Conclusions: Additional large postmortem studies are needed to clarify the role of SARS-CoV in the ophthalmic and neuropathologic manifestations of COVID-19.
Subject Brain; COVID-19; Eye Diseases; Nervous System Diseases; Pandemics
OCR Text Show
Date 2021-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2016, Volume 41, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s63qc71c
Setname ehsl_novel_jno
ID 2033201
Reference URL https://collections.lib.utah.edu/ark:/87278/s63qc71c
Back to Search Results