Interocular Difference in Retinal Nerve Fiber Layer Thickness Predicts Optic Neuritis in Pediatric-Onset Multiple Sclerosis

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Title Interocular Difference in Retinal Nerve Fiber Layer Thickness Predicts Optic Neuritis in Pediatric-Onset Multiple Sclerosis
Creator Amy T. Waldman, MD, MSCE; Leslie Benson, MD; John R. Sollee, BS; Amy M. Lavery, PhD; Geraldine W. Liu, ALM; Ari J. Green, MD, MCR; Emmanuelle Waubant, MD; Gena Heidary, MD, PhD; Darrel Conger, CRA; Jennifer Graves, MD, PhD; Benjamin Greenberg, MD, MHS
Affiliation Division of Neurology (ATW, JRS, AML, GWL), Children's Hospital of Philadelphia and Departments of Neurology and Pediatrics (ATW), Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania; Departments of Neurology (LB) and Ophthal- mology (GH), Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts; Division of Neuroimmunology and Glial Biology (AJG, EW), Department of Neurology, Weill Institute of Neurosciences, University of California San Francisco, San Francisco, Cal- ifornia; Department of Neurology and Neurotherapeutics (DC, BG), University of Texas Southwestern Medical Center, Dallas, Texas; Department of Neurology, University of California San Diego, San Diego, California; and Department of Ophthalmology (AJG), University of California San Francisco, San Francisco, California
Abstract Optical coherence tomography (OCT) is capa- ble of quantifying retinal damage. Defining the extent of anterior visual pathway injury is important in multiple sclerosis (MS) as a way to document evidence of prior disease, including subclinical injury, and setting a baseline for patients early in the course of disease. Retinal nerve fiber layer (RNFL) thickness is typically classified as low if values fall outside of a predefined range for a healthy population. In adults, an interocular difference (IOD) in RNFL thickness greater than 5 mm identified a history of unilateral optic neuritis (ON).
Subject OCT; Multiple Sclerosis; PERCEPTION
OCR Text Show
Date 2021-12
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, December 2021, Volume 41, Issue 4
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s67m5e65
Setname ehsl_novel_jno
ID 2116240
Reference URL https://collections.lib.utah.edu/ark:/87278/s67m5e65
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