| Identifier |
20080310_nanos_sciplatform_05.pdf |
| Title |
Orally Administered SIRTl Activator SRT501 is Neuroprotective for Retinal Ganglion Cells and Suppresses Neurological Dysfunction in a Mouse Model of Multiple Sclerosis |
| Creator |
Kenneth S. Shindler; Elvira Ventura; Peter Elliott; A.M. Rostami |
| Affiliation |
(KSS) University of Pennsylvania, Philadelphia, PA; (EV) (AMR) Thomas Jefferson University Philadelphia, PA; (PE) Sirtris Pharmaceuticals, Cambridge, MA |
| Subject |
Optic Neuritis; Neuroprotection; Retinal Ganglion Cells; Multiple Sclerosis; EAE |
| Description |
Neuronal loss in multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE), correlates with permanent neurological dysfunction. Intravitreal injection of compounds that activate SIRTl, an NAD+-dependent deacetylase involved in cellular stress resistance and survival, attenuates retinal ganglion cell (RGC) loss during acute optic neuritis in EAE mice. |
| Date |
2008-03-10 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2008 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2008: Platform Session I |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6dr61t8 |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Setname |
ehsl_novel_nam |
| ID |
180792 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6dr61t8 |
