Mathematical models of mechanisms underlying long-term type 2 diabetes progression

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Title Mathematical models of mechanisms underlying long-term type 2 diabetes progression
Publication Type dissertation
School or College College of Science
Department Mathematics
Author Graham, Erica J.
Date 2012-08
Description We develop a series of mathematical models incorporating proposed mechanisms underlying the development of two essential features of long-term type 2 diabetes progression: insulin resistance and ¯-cell dysfunction. Reduced insulin-stimulated plasma glucose uptake (insulin resistance) and inadequate insulin production by ¯ cells (¯-cell dysfunction) lead to a number of metabolic irregularities. We study the interaction of oxidative stress and mitochondrial dysfunction in the development of skeletal muscle insulin resistance, focusing on mitochondrial superoxide production and the functional and physical heterogeneities among mitochondria. We explore primary determinants in ¯-cell failure, from the perspective of endoplasmic reticulum stress and the unfolded protein response. We conclude with a basis for age-related insulin resistance, an explanation of the fundamental role of nutrient excess in the decline of metabolic health, and an identification of the interplay of cellular and molecular mechanisms important in metabolic dysregulation.
Type Text
Publisher University of Utah
Subject Beta-cell dysfunction; Insulin resistance; Mathematical biology; Mathematical modeling; Mathematical physiology; Type 2 diabetes
Subject LCSH Non-insulin-dependent diabetes -- Mathematical models
Dissertation Institution University of Utah
Dissertation Name Doctor of Philosophy
Language eng
Rights Management Copyright © Erica J. Graham 2012
Format application/pdf
Format Medium application/pdf
Format Extent 3,149,300 bytes
Identifier etd3/id/1794
Source Original in Marriott Library Special Collections, RC39.5 2012 .G73
ARK ark:/87278/s634916b
Setname ir_etd
ID 195483
Reference URL https://collections.lib.utah.edu/ark:/87278/s634916b
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