Retinal Nerve Fiber Layer Thickness Using Spectral-Domain Optical Coherence Tomography in Patients With No Light Perception Secondary to Optic Atrophy

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Title Retinal Nerve Fiber Layer Thickness Using Spectral-Domain Optical Coherence Tomography in Patients With No Light Perception Secondary to Optic Atrophy
Creator Sylvia L. Groth, BA; Andrew Harrison, MD; Alana L. Grajewski, MD; Michael S. Lee, MD
Affiliation Department of Ophthalmology, University of Minnesota, Minneapolis, Minnesota
Abstract Optical coherence tomography (OCT) provides useful structural information that can augment functional data. Newer spectral-domain technology provides faster and higher resolution images than time-domain machines. Although each measures the same structures, the values systematically differ. We evaluated eyes with longstanding no light perception (NLP) visual acuity secondary to optic atrophy using spectral-domain OCT to determine minimum retinal nerve fiber layer (RNFL) thickness. The authors conducted a retrospective, crosssectional chart review study to identify patients with NLP acuity for 8 months or more and having a good quality Spectralis OCT (Heidelberg Engineering, Heidelberg, Germany) to measure the RNFL thickness. An unpaired t test compared the eyes with a previously published data set measured with time-domain OCT. Eleven eyes from 10 patients were examined with the Spectralis OCT. The mean duration of documented NLP acuity was 3.72-1.20 years. The mean RNFL thickness was 34.18 - 2.66 mm (95% coincidence interval, 28.26 40.11 mm). Mean RNFL thickness was significantly thinner on this spectral-domain OCT than previously published values on time-domain OCT (34.18 vs 45.42 mm, P = 0.004). Using the Spectralis OCT, mean RNFL thickness for NLP eyes due to optic atrophy is 28-40 mm. This provides clinicians useful information when considering how aggressively to manage patients with optic nerve disease.
Subject Adult; Older people, 80 and over; Cross-Sectional Studies; Female; Humans; Light; Male; Middle Older people; Nerve Fibers; Optic Atrophy; Retinal Neurons; Retrospective Studies; Tomography, Optical Coherence; Visual Acuity
OCR Text Show
Date 2013-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6rf915w
Setname ehsl_novel_jno
ID 227376
Reference URL https://collections.lib.utah.edu/ark:/87278/s6rf915w
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