Sensory axon guidance molecules in avian skin

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Title Sensory axon guidance molecules in avian skin
Publication Type dissertation
School or College School of Medicine
Department Neurobiology & Anatomy
Author Cahoon-Metzger, Sharon M.
Date 1999-12
Description The goal of this dissertation research was to identify and begin to characterize the contribution of two classes of molecules, chondroitin sulfate proteoglycans (CSPGs) and neurotrophins (NTs) in patterning the innervation of avian skin. In particular, we investigate the role of these molecules in restricting axons to dermis in avian skin. The work described in Chapter 2 demonstrates that, while CSPGs contribute to the avoidance of chick epidermis by cutaneous sensory neurites, they are clearly not solely responsible. Chapter 3 details the possible inhibitory contribution of a member of an additional class of molecules, the neurotrophins (NTs), involved in patterning and maintaining sensory innervation. Our data implicate BDNF as an inhibitory component of chick epidermis that prevents sensory neurites from invading it. Neuronal development, which includes pathfinding, target selection and ramification with the correct target, is complex. Here we have utilized a system that allowed us to tease out at least part of the complex picture. By studying avian cutaneous innervation, we have proposed a model with multifactorial control or two classes of inhibitory guidance molecules (CSPGs and NTs) in this system. Using this more simplified system, it has become more increasingly clear how complex the scenario is-even at this level.
Type Text
Publisher University of Utah
Subject Innervation
Subject MESH Skin
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Sensory axon guidance molecules in avian skin". Spencer S. Eccles Health Sciences Library.
Rights Management © Sharon M. Cahoon-Metzger.
Format application/pdf
Format Medium application/pdf
Format Extent 1,865,616 bytes
Identifier undthes,4243
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available)
Funding/Fellowship NIHNS grant 16067 to SAS and 2 University Of Utah Graduate Research Dissertation Fellowship to SMC-M; Interdepartmental Program in Neuroscience; The Department of Neurobiology and Anatomy
Master File Extent 1,865,621 bytes
ARK ark:/87278/s6v40x2q
Setname ir_etd
ID 191653
Reference URL https://collections.lib.utah.edu/ark:/87278/s6v40x2q
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