Genomic approach to the study of chromatin and transcription

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Title Genomic approach to the study of chromatin and transcription
Publication Type dissertation
School or College School of Medicine
Department Oncological Sciences
Author Roberts, Douglas N.
Date 2004-12
Description The eukaryotic cell has developed complex regulatory circuitry to ensure proper gene expression. An important aspect of this regulation involves the modulation of the basal transcriptional machinery as well as nucleosomal chromatin substrates. Both covalent histone modification and the physical movement or positioning of nucleosomes can impart regulatory functions on transcription. This work describes genomic approaches to study chromatin modification and how it affects transcription in the yeast Saccharomyces cerevisiae. Specifically, we define the in vivo DNA targets of the ATP-dependent chromatin remodeler RSC (Remodels the Structure of Chromatin). We also examine the recruitment and regulation of the basal machinery for RNA polymerase III. Finally, we provide evidence for novel transcriptional roles for the histone acetyltransferase complexes SAGA (Spt-Ada-Gcn5-Acetyltransferase) and Elongator. These studies have provided a better understanding of the relationships between chromatin and gene regulation.
Type Text
Publisher University of Utah
Subject Genetics; Gene Regulation; Eukaryotic Cell
Subject MESH Transduction, Genetic; Chromatin; Saccharomyces cerevisiae
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "A genomic approach to the study of chromatin and transcription". Spencer S. Eccles Health Sciences Library. Print version of "A genomic approach to the study of chromatin and transcription" available at J. Willard Marriott Library Special Collection. QH9.7 2004 .R62.
Rights Management © Douglas N. Roberts.
Format application/pdf
Format Medium application/pdf
Format Extent 8,766,574 bytes
Identifier undthes,4564
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 8,766,633 bytes
ARK ark:/87278/s6gf0w8p
Setname ir_etd
ID 190579
Reference URL https://collections.lib.utah.edu/ark:/87278/s6gf0w8p
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