Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease

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Title Retinal Nerve Fiber Layer Thickness in Patients With Alzheimer Disease
Creator Serkan Kirbas, MD; Kemal Turkyilmaz, MD; Omer Anlar, MD; Ahmet Tufekci, MD; Mustafa Durmus, MD
Affiliation Departments of Neurology and Ophthalmology, Faculty of Medicine, Rize University, Rize, Turkey
Abstract The aim of this study was to investigate retinal nerve fiber layer (RNFL) thickness in patients with Alzheimer disease (AD) without visual impairment using spectral domain optical coherence tomography (SD-OCT) and to compare the results with healthy controls. A total of 80 subjects, including 40 patients with early untreated AD (mean age, 69.3 - 4.9 years) and 40 healthy controls (mean age, 68.9 - 5.1 years) were enrolled. Both eyes of patients with AD and controls were imaged using SD-OCT. The average RNFL thickness was significantly less in the AD patients than in controls (65 - 6.2 mm vs 75 - 3.8mm; P = 0.001). There was selective thinning of the RNFL in the superior quadrant, the mean superior quadrant RNFL thickness being 76 - 6.7 mm in AD patients and 105 - 4.8 mm in controls (P = 0.001). In our study, the thickness of RNFL in patient with AD was lower than that of controls. This suggests that SD- OCT has the potential to be used in the early diagnosis of AD as well as in the study of therapeutic agents Further studies are needed to validate this technology as a viable ocular biomarker over time in AD.
Subject Older people; Older people, 80 and over; Alzheimer Disease; Female; Humans; Male; Middle Older people; Nerve Fibers; Retinal Neurons; Tomography, Optical Coherence
OCR Text Show
Date 2013-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s67d6183
Setname ehsl_novel_jno
ID 227380
Reference URL https://collections.lib.utah.edu/ark:/87278/s67d6183
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