The QuantiFERON-TB Gold In-Tube Assay in Neuro-Ophthalmology

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Title The QuantiFERON-TB Gold In-Tube Assay in Neuro-Ophthalmology
Creator Leanne M. Little, BS; Mohammed Rigi, MD; Ayman Suleiman, MD; Stacy V. Smith, MD; Edward A. Graviss, PhD, MPH; Rod Foroozan, MD; Andrew G. Lee, MD
Affiliation Baylor College of Medicine (LML), Houston, Texas; Department of Ophthalmology (MR, AS, SVS), Department of Ophthalmology (EAG), Blanton Eye Institute, Houston Methodist Hospital; Department of Ophthalmology (RF), Baylor College of Medicine, Houston, Texas; Blanton Eye Institute of Houston Methodist Hospital (AGL), Houston, Texas; Department of Ophthalmology, Neurology, and Neurosurgery (AGL), Weill Cornell Medical College; Department of Ophthalmology (AGL), University of Texas Medical Branch, Galveston, Texas; Department of Ophthalmology (AGL), University of Texas MD Anderson Cancer Center, Houston, Texas; Department of Ophthalmology (AGL), Baylor College of Medicine, Houston, Texas; and Department of Ophthalmology (AGL), The University of Iowa Hospitals and Clinics, Iowa City, Iowa
Abstract Although QuantiFERON-TB Gold In-Tube (QFT-GIT) testing is regularly used to detect infection with Mycobacterium tuberculosis, its utility in a patient population with a low risk for tuberculosis (TB) has been questioned. The following is a cohort study analyzing the efficacy of QFT-GIT testing as a method for detection of active TB disease in low-risk individuals in a neuro-ophthalmologic setting. Ninety-nine patients from 2 neuro-ophthalmology centers were identified as having undergone QFT-GIT testing between January 2012 and February 2016. Patients were divided into groups of negative, indeterminate, and positive QFT-GIT results. Records of patients with positive QFT-GIT results were reviewed for development of latent or active TB, as determined by clinical, bacteriologic, and/or radiographic evidence. Of the 99 cases reviewed, 18 patients had positive QFT-GIT tests. Of these 18 cases, 12 had documentation of chest radiographs or computed tomography which showed no evidence for either active TB or pulmonary latent TB infection (LTBI). Four had chest imaging which was indicative of possible LTBI. None of these 18 patients had symptoms of active TB and none developed active TB within the follow-up period. Based on our results, we conclude that routine testing with QFT-GIT in a low-risk cohort did not diagnose active TB infection. We do not recommend routine QFT-GIT testing for TB low-risk individuals, as discerned through patient and exposure history, ocular examination, and clinical judgment, in neuro-ophthalmology practice.
Subject Adult; Older people; Antigens, Bacterial; Equipment Design; Female; Humans; Interferon-gamma Release Tests; Latent Tuberculosis; Latent Tuberculosis; Male; Middle Older people; Mycobacterium tuberculosis; Mycobacterium tuberculosis; Neurology; Ophthalmology; Reproducibility of Results; Retrospective Studies; Tuberculin Test
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Date 2017-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Source Journal of Neuro-Ophthalmology, September 2017, Volume 37, Issue 3
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6h74q0s
Setname ehsl_novel_jno
ID 1374441
Reference URL https://collections.lib.utah.edu/ark:/87278/s6h74q0s
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