Some neurophysiological and neurochemical characteristics of audiogenic-seizure-susceptible mice

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Title Some neurophysiological and neurochemical characteristics of audiogenic-seizure-susceptible mice
Publication Type thesis
School or College College of Pharmacy
Department Pharmacology & Toxicology
Author Castellion, Alan William
Contributor Woodbury, Dixon M.
Date 1964-08
Description From the results presented, it can be concluded that there are no differences in the maturation of the central nervous systems of audiogenic-seizure-susceptible and non-susceptible mice. The ability of audiogenic-seizure-susceptible animals to respond to sound with a convulsion decreases with increased age, whereas the ability of mice to respond to electroshock with a maximal seizure is retained throughout life. Audiogenic-seizure-susceptible mice differ in at least two ways from CF #1 mice. First, the oscillator mechanism of audiogenic-seizure mice is more sensitive to discharge by electric current, and second, seizure spread is more easily evoked in these mice. Furthermore, maximal audiogenic-seizure (F-MS and 0-MS) mice differ in at least two ways from non-susceptible (F-NS, 0-NS, and CF #l) mice. First, maximal audiogenic-seizure mice are more susceptible to supramaximal electroshock than non-susceptible mice, and second, maximal audiogenic-seizure mice respond to supramaximal electroshock with a more severe seizure than non-susceptible mice. Maximal audiogenic seizures are more severe in F-MS mice than in 0-MS animals. Plasma potassium levels are higher in 0-MS mice than in 0-NS or CF #1 mice. Finally, the ability of sound to induce a seizure in F-MS and not in F-NS mice is best explained by the lower thyroid activity of the F-NS mice, but decreased thyroid activity cannot explain the genetic difference in audiogenic-seizure susceptibility between Frings and CF #1 mice.
Type Text
Publisher University of Utah
Subject Convulsions; Electroschock-Seizure Threshold
Subject MESH Mice; Seizures; Sound
Dissertation Institution University of Utah
Dissertation Name PhD
Language eng
Relation is Version of Digital reproduction of "Some neurophysiological and neurochemical characteristics of audiogenic-seizure-susceptible mice." Spencer S. Eccles Health Sciences Library. Print version of "Some neurophysiological and neurochemical characteristics of audiogenic-seizure-susceptible mice." available at J. Willard Marriott Library Special Collection. RC39.5 1964 .C38.
Rights Management © Alan W. Castellion.
Format application/pdf
Format Medium application/pdf
Format Extent 3,488,496 bytes
Identifier undthes,4924
Source Original: University of Utah Spencer S. Eccles Health Sciences Library (no longer available).
Master File Extent 3,488,518 bytes
ARK ark:/87278/s6ww7kf2
Setname ir_etd
ID 190894
Reference URL https://collections.lib.utah.edu/ark:/87278/s6ww7kf2
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