Lambert-Eaton Myasthenic Syndrome: Ocular Signs and Symptoms

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Title Lambert-Eaton Myasthenic Syndrome: Ocular Signs and Symptoms
Creator Jeffery D. Young, MD; Jacqueline A. Leavitt, MD
Affiliation Department of Surgery (JDY), Division of Ophthalmology, University of Vermont College of Medicine, Burlington, Vermont; and Department of Ophthalmology (JAL), Mayo Foundation, Mayo Clinic, Rochester, Minnesota
Abstract The demographic associations among patients presenting with myasthenia gravis with only ocular manifestations (OMG) is not clear.; ; In this 5-center case series, we collected the race, gender, and age at diagnosis of patients diagnosed with myasthenia gravis who had no signs or symptoms of generalized myasthenia gravis (GMG). An a priori sample size calculation determined that 140 patients were required to accept that there was a ≤10-year difference in mean age (equivalence testing: power 90%, α = 0.05). Robust Bayesian analysis and linear regression were applied to evaluate whether age differed by gender or race.; ; Of 433 patients included, 258 (60%) were men. Mean age among men was 57 years (SD = 19) and 52 years (SD = 21) among women. The 95% credible interval (CI) (Bayesian equivalent of confidence interval) was 0.8-8.7 years for mean age, and there was a 99.6% probability that the mean difference in age between sexes was <10 years. Race was documented in 376 (68 [18%] non-Caucasian). Caucasians were 17.3 years older than non-Caucasians at diagnosis (95% CI, 12.2-22.3 y; P < 0.001) controlling for gender. There was no additive interaction of gender and race (P = 0.74). There was a bimodal distribution for women peaking around 30 and 60 years. Men had a left skewed unimodal age distribution peaking at age 70.; ; The distribution of age at presentation in patients with OMG is different between men and women, similar to GMG. Non-Caucasian patients tend to develop OMG at a younger age.
Subject Adolescent; Adult; Older people; Older people, 80 and over; Blepharoptosis; Child; Diplopia; Dry Eye Syndromes; Female; Humans; Lambert-Eaton Myasthenic Syndrome; Male; Middle Older people; Ocular Motility Disorders; Retrospective Studies; Strabismus; Vision Disorders; Visual Acuity
OCR Text Show
Date 2016-03
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s6m080x7
Setname ehsl_novel_jno
ID 1276448
Reference URL https://collections.lib.utah.edu/ark:/87278/s6m080x7
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