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Progressive Multifocal Leukoencephalopathy: Recent Advances and a Neuro-Ophthalmologlcal Review

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Title Journal of Neuro-Ophthalmology, September 2015, Volume 35, Issue 3
Date 2015-09
Language eng
Format application/pdf
Type Text
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
ARK ark:/87278/s62j9hxc
Setname ehsl_novel_jno
ID 227767
Reference URL https://collections.lib.utah.edu/ark:/87278/s62j9hxc

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Title Progressive Multifocal Leukoencephalopathy: Recent Advances and a Neuro-Ophthalmologlcal Review
Creator Padmaja Sudhakar; David M. Bachman; Alexander S. Mark; Joseph R. Berger; Sachin Kedar
Abstract BACKGROUND: Progressive multifocal leukoencephalopathy (PML) is a severe often fatal opportunistic infection of the central nervous system caused by reactivation of a ubiquitous polyoma virus, JC virus. Although typically characterized by multifocal asymmetric subcortical white matter lesions, it may be monofocal and affect the cortical gray matter. Among the broad spectrum of clinical manifestations that occurs with PML, visual complaints are common. EVIDENCE ACQUISITION: Combination of representative personally observed cases of PML and comprehensive review of case series of PML from 1958 through 2014. RESULTS: Neuro-ophthalmic signs and symptoms were reported in approximately 20%-50% of patients with PML and can be the presenting manifestation in half of these. A majority of these presentations occur from damage to cerebral visual pathways resulting in visual field defects, cortical blindness, and other disorders of visual association. Given the decreased frequency of infratentorial and cerebellar involvement, ocular motility disorders are less common. CONCLUSIONS: Visual complaints occur in patients with PML and are often the presenting sign. Awareness of this condition is helpful in avoiding unnecessary delays in the diagnosis of PML and management of the underlying condition. Recent guidelines have established criteria for diagnosis of PML in the high-risk patient population and strategies to mitigate the risk in these populations.
Subject Adult; Brain; Female; Humans; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Male; Middle Older people; Neurology; Ophthalmology; Visual Pathways
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Format application/pdf
Publication Type Journal Article
Collection Neuro-Ophthalmology Virtual Education Library: Journal of Neuro-Ophthalmology Archives: https://novel.utah.edu/jno/
Publisher Lippincott, Williams & Wilkins
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management © North American Neuro-Ophthalmology Society
Setname ehsl_novel_jno
ID 227752
Reference URL https://collections.lib.utah.edu/ark:/87278/s62j9hxc/227752
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