| Identifier |
20230314_nanos_posters_226 |
| Title |
Estrogen Induces IL-1β to Mediate Retinal Ganglion Cell Loss in Murine Optic Glioma |
| Creator |
Yunshuo Tang; Jit Chatterjee; Ngan Wagoner; David Gutmann |
| Affiliation |
(YT) (JC) (NW) (DG) Washington University in Saint Louis |
| Subject |
Tumors; Optic Neuropathy; Pediatric Neuro-ophthalmology; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid) |
| Description |
Optic pathway glioma (OPG) is a low-grade astrocytoma seen in 15-20% of children with the neurofibromatosis type 1 (NF1) cancer predisposition syndrome. While not fatal, 30-50% of children with NF1-OPG exhibit retinal ganglion cell (RGC) death and vision loss, which is three times more frequent in girls. Using murine Nf1-OPG models, we previously demonstrated that estrogen acts at the level of microglia to induce RGC death. Herein, we present evidence that estrogen mediates RGC death through IL-1β. |
| Date |
2023-03-14 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2023 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS Annual Meeting 2023: Poster Session II: Disorders of the Anterior Visual Pathway (Retina, Optic Nerve, and Chiasm) |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2023. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6q1ty92 |
| Setname |
ehsl_novel_nam |
| ID |
2335431 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6q1ty92 |
