Identifier |
20220215_nanos_sciplatform3_04 |
Title |
Continuous Hypoxia Reduces Retinal Ganglion Cell Degeneration in a Mouse Model of Mitochondrial Optic Neuropathy |
Creator |
Sidney Gospe III; Alexander Warwick; Howard Bomze; Vadim Arshavsky |
Affiliation |
(SG) (AW) (HB) (VA) Duke University Medical Center, Durham, North Carolina |
Subject |
Optic Neuropathy; Neuro-ophthalmology & Systemic Disease (eg. MS, MG, Thyroid) |
Description |
Primary optic atrophy resulting from death of retinal ganglion cells (RGCs) is the most prominent ocular manifestation of mitochondrial disease. We have recently developed a genetic mouse model of rapidly-progressive mitochondrial optic neuropathy in which RGCs experience severe dysfunction of mitochondrial respiratory complex I due to conditional deletion of the accessory subunit ndufs4 within RGCs.1 While continuous hypoxia was previously shown to prolong the lifespan of the Leigh syndrome model ndufs4 knockout mouse bearing a global deletion of the gene, any effect of hypoxia on RGC survival has not been reported. |
Date |
2022-02 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2022 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2022: Scientific Platform III |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2022. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6q09vry |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
2193622 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6q09vry |