Amblyopia Recovery Following Contralateral Vision Loss: Retrospective Chart Review and Analysis of Reported Cases

Recovery from amblyopia in adulthood following fellow eye (FE) vision loss is a well-established phenomenon, but potentially influential clinical factors remain unclear. Animal models suggest that limiting retinal ganglion cell (RGC) activity, as occurs in ischemic optic neuropathy (ION), drives recovery after critical period closure. In this two-part study we 1) quantify amblyopic eye (AE) visual acuity (VA) recovery following contralateral ION, and 2) define the relationships between improvement, mechanism of FE pathology, and magnitude of vision loss statistically using previously reported cases.