Identifier |
20160301_nanos_sciplatform2_12 |
Title |
The Effect of Red Light Exposure on the Pre-Existing Melanopsin-Driven Post-Illumination Pupil Response (.pdf) |
Creator |
Shaobo Lei; Herbert C. Goltz; Jaime Sklar; Agnes M. F. Wong |
Affiliation |
(SL) (HCG) (JS) (AMFW) Program in Neurosciences and Mental Health, University of Toronto, Toronto, ON, Canada; (AMFW) Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada; (HCG) (AMFW) The Hospital for Sick Children Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, ON, Canada |
Subject |
Pupil Light Reflex, Chromatic Pupillometry, Melanopsin, Post-Illumination Pupil Response |
Description |
"Intrinsically photosensitive retinal ganglion cells (ipRGCs), the specific sub-group of retinal ganglion cells that mediate the pupillary light reflex, contain a bistable photo-pigment called melanopsin. The activation of melanopsin drives a persistent firing of ipRGCs resulting in a sustained pupil constriction after the offset of light stimulation (post-illumination pupil response, PIPR). It has been proposed that after activation by blue light, activated melanopsin is converted back to its resting state by long wavelength light exposure, a putative mechanism of melanopsin chromophore recovery in vivo. We tested this hypothesis by investigating hether red light attenuates the ongoing post-illumination pupil response (PIPR) induced by melanopsin-activating blue light. " |
Date |
2016-03-01 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2016 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2016: Scientific Platform Session II |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
ARK |
ark:/87278/s6420403 |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
185330 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6420403 |