Distractibility In Multiple Sclerosis

Objective: To undertake a pilot study to elucidate objective and reproducible ocular motor abnormalities reflecting cognitive dysfunction in multiple sclerosis (MS). MS patients near universally suffer fatigue and impaired concentration, often prior to clinically evident 'eloquent' lesions. Pathology in MS is diffuse, affecting widespread interconnecting networks subserving cognition. Dysfunction in these networks represents the commonest manifestations of MS impacting gainful employment, provoking demoralization, and compromising quality of life. An ominous consequence of cognitive impairment involves the predilection for dysphoria, reduced socialization and abulia, compromising adherence to treatment and healthy living.