The Idiopathic Intracranial Hypertension Treatment Trial: Clinical Profile at Baseline

Treatment of idiopathic intracranial hypertension (IIH) is based on anecdotal uncontrolled data as there are no properly designed and executed clinical trials to guide therapy. With this in mind, investigators of the Neuro- Ophthalmology Research Disease Consortium (NORDIC) study group developed the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT), a multicenter, double-blind, randomized, placebo-controlled study of 165 subjects with mild visual loss. All subjects received a lifestyle modification program of weight-reduction with a low sodium diet. Additionally, subjects were randomized to receive either acetazolamide or matching placebo. The baseline clinical and laboratory features of enrolled IIHTT subjects are detailed here.