| Identifier |
20140304_nanos_posters_217 |
| Title |
Cyanocobalamin is a Superoxide Anion Scavenger and Neuroprotectant in Neuronal Cells |
| Creator |
Wesley Chan; Maria-Magdalena Catrinescu; Leonard A. Levin |
| Affiliation |
(WC) University of Calgary, Undergraduate Medicine, Calgary, AB, Canada; (WC) (MC) (LAL) University of Montreal, Department of Ophthalmology, Montreal, QC, Canada; (MC) (LAL) McGill University, Department of Ophthalmology, Montreal, QC, Canada; (LAL) University of Wisconsin Madison, Department of Ophthalmology and Visual Sciences Madison, WI |
| Subject |
Vitamin B12 Deficiency; Optic Neuropathy; Bilateral Centrocecal Scotoma; Superoxide Dismutase; Cyanocobalamin |
| Description |
Vitamin B12 deficiency can cause an optic neuropathy characterized by bilateral centrocecal scotomas. The mechanism for this is not well understood. In 2009, another group demonstrated that vitamin B12 scavenges superoxide as effectively as superoxide dismutase (SOD). Our prior work showed that retinal ganglion cells (RGC) axotomy induced a burst of superoxide that then led to RGC death. We hypothesized that superoxide scavenging by cyanocobalamin, the most abundant vitamin B12 vitamer, would be neuroprotective, and studied this in vitro and in vivo. |
| Date |
2014-03-04 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2014 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2014: Poster Presentations |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6sj4sbp |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Setname |
ehsl_novel_nam |
| ID |
184009 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6sj4sbp |
