| Identifier |
20130212_nanos_sciplatform2_01 |
| Title |
A Phase I Open Label, Dose Escalation Trial Of QPI-1007 Delivered By A Single Intravitreal (IVT) Injection To Subjects With Low Visual Acuity And Acute Non-Arteritic Anterior Ischemic Optic Neuropathy (NAION) |
| Creator |
Bradley J. Katz; A. Antoszyk; R. P. Singh; R. Gurses-Ozden; S. Erlich; D. Rothenstein; N. Sharon; J. Hodge; L. A. Levin; N. R. Miller; QPI-1007 NAION Study Group |
| Affiliation |
(BJK) University of Utah Health Sciences Center, Salt Lake City, UT; (AA) Charlotte Eye Ear Nose & Throat Associates, Charlotte, NC; (RPS) Cleveland Clinic Foundation, Cleveland, OH; (SE) (DR) (NS) (JH) Quark Pharmaceuticals, Inc., Fremont, CA; (LAL) McGill University, Montreal, QC, Canada; (LAL) University of Wisconsin, Madison, WI; (NRM) Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD; (QPI) Various Insitutions in Israel and the USA |
| Subject |
Ischemic Optic Neuropathy; Intravitreal Injection; Caspase 2; siRNA; QPI-1007 |
| Description |
Subjects with stable low vision due to posterior segment pathology and subjects with acute onset NAION were enrolled in a 2 strata, Phase I, multi-center, open-label, and dose escalation study to determine safety, tolerability, and the structural and functional changes after single IVT injection of QPI-1007, a synthetic, chemically modified siRNA that inhibits expression of caspase 2. |
| Date |
2013-02-12 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2013 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2013: Platform Presentations (Session II) |
| Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
| Publisher |
North American Neuro-Ophthalmology Society |
| Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6kq17t2 |
| Setname |
ehsl_novel_nam |
| ID |
183283 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6kq17t2 |
