Identifier |
20210222_nanos_sciplatform2_02-abstract |
Title |
Ectopic Melanopsin for Visual Restoration: Compressed Cell-Specific Promotors - a Translatable Delivery Mechanism |
Creator |
Michael Gilhooley; Moritz Lindner; Steven Hughes; Mark Hankins |
Affiliation |
(MG) University of Oxford & Moorfields Eye Hospital, Oxford, United Kingdom of Great Britain and Northern Ireland; (ML) Institute of Physiology and Pathophysiology, Philipps University, Marburg, Germany; (SH) (MH) University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland |
Subject |
Genetic Disease; Retina; Pupil; Miscellaneous |
Description |
Exogenous expression of Melanopsin renders neural cells sensitive to light. It is a prime candidate for clinical optogenetic approaches to visual restoration,especially when applied to theneuroretinal tissue surviving ininherited retinal degenerations (IRDs). We previously demonstrated that targeting expression of melanopsin to retinal ON-bipolar cells, using a transgenic ‘Cre.lox' model, led to the restoration of more naturalistic response characteristics in an IRD. However, an alternativeclinically translatable mechanism of targeting melanopsin is required to allow therapeutic use. |
Date |
2021-02 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2021 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2021: Scientific Platform Session II |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2021. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6rg1q3k |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1671206 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6rg1q3k |