Ectopic Melanopsin For Visual Restoration: Comparisons with Alternative Optogenetic Tools (Video)
Creator
Michael Gilhooley; Moritz Lindner; Steven Hughes; Mark Hankins
Affiliation
(MG) University of Oxford & Moorfields Eye Hospital, Oxford, United Kingdom of Great Britain and Northern Ireland; (ML) Institute of Physiology and Pathophysiology, Philipps University, Marburg, Germany; (SH) (MH) University of Oxford, Oxford, United Kingdom of Great Britain and Northern Ireland
Subject
Genetic Disease; Pupil; Retina
Description
Background: Melanopsin is an optogenetic tool - it renders neural cells sensitive to light when exogenously expressed - and is emerging as a prime candidate for clinical optogenetic approaches to visual restoration. A model for this approach lies in the neuroretinal tissue surviving in the inherited retinal degenerations (IRD). However, a diversity of neural light responses naturally exists in the healthy retinae and it remains unclear which optogenetic tool is best suited to fully replicate natural neuroretinal responses. Purpose: To compare melanopsin with leading optogenetic tools exogenously targeted to ON-bipolar cells without the 'noise' of intrinsic responses by using retinae devoid of both canonical and pRGC photoreception.
Date
2020-03
Language
eng
Format
video/mp4
Type
Image/MovingImage
Source
2020 North American Neuro-Ophthalmology Society Annual Meeting
Relation is Part of
NANOS Annual Meeting 2020: Scientific Platform Session III