Identifier |
20200310_nanos_sciplatform3_04-slides |
Title |
Development of a Retinal Ganglion Cell Specific Gene Therapy Using SIRT1 Signaling for Neuro-Protection (Slides) |
Creator |
Ahmara G. Ross; Devin McDougald; Reas Khan; Thu Duong; Kimberly Dine; Puya Aravand; Natalia Tavares; Jean Bennett; Kenneth Shindler |
Affiliation |
(AR) University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania; (DM) (JB) Center for Advanced Retinal and Ocular Therapeutics, Philadelphia, Pennsylvania; (RK) (RD) (KD) (PA) (NT) (KS) University of Pennsylvania/Ophthalmology, Philadelphia, Pennsylvania |
Subject |
Optic Neuropathy; Optic Nerve Trauma and Treatment; Orbit/Ocular Pathology; Miscellaneous |
Description |
Loss of retinal ganglion cells (RGC) can occur by trauma, inflammatory, and ischemia leading to irreversible effects upon vision. Sirtuin 1 (SIRT1) deacetylase has demonstrated therapeutic value in multiple models of optic neuropathy with small molecule biologics. The initial use of gene therapy modestly improved visual outcomes in the EAE-induced mouse model of optic neuritis but with limited effects due to a low transduction rate and lack of cell specificity. Here we investigated the therapeutic potential of RGC specific SIRT1 gene augmentation in a mouse model of optic nerve crush (ONC). |
Date |
2020-03 |
Language |
eng |
Format |
application/pdf |
Format Creation |
Microsoft PowerPoint |
Type |
Text |
Source |
2020 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2020: Scientific Platform Session III |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s64f70kh |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1540456 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s64f70kh |