Fundus Autofluorescence

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Identifier EEC_AF_NOVEL
Title Fundus Autofluorescence
Creator Jonathan A. Micieli, MD; Valérie Biousse, MD
Affiliation (JAM) Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia; (VB) Cyrus H. Stoner Professor of Ophthalmology, Professor of Ophthalmology and Neurology, Departments of Ophthalmology and Neurology, Emory University School of Medicine, Atlanta, Georgia
Subject Ocular and Neurologic Evaluation, Fundus Autofluorescence
Description The retinal pigment epithelium (RPE) has many important functions including phagocytosis of the photoreceptor outer segments. The metabolism of the photoreceptor outer segments leads to the formation of lipofuscin. Disease states and potentially increased oxidative damage can lead to the buildup of lipofuscin in the RPE (Figure 1). When stimulated with a broad wavelength of light, lipofuscin autofluoresces (Figure 2). Excess accumulation of lipofuscin leads to hyperautofluorescence whereas death of absence of the RPE leads to the disappearance of lipofuscin and hypoautofluorescence (Figure 3). The primary methods of obtaining fundus autofluorescence images include confocal scanning laser ophthalmoscopy and modified fundus photography. A normal fundus autofluorescence image is shown in Figures 4 and 5 and case examples of bilateral central scotomas from a macular dystrophy (Figures 6 and 7), acute macular neuroretinopathy (Figures 8 and 9), bull's-eye maculopathy from chloroquine toxicity (Figures 10 and 11), and pseudopapilledema from optic disc drusen (Figures 12 and 13) are shown.
Date 2018-03
Language eng
Format application/pdf
Format Creation Microsoft PowerPoint
Type Text
Collection Neuro-Ophthalmology Virtual Education Library: The Emory Eye Center Collection: https://novel.utah.edu/eec/
Publisher North American Neuro-Ophthalmology Society
Holding Institution Spencer S. Eccles Health Sciences Library, University of Utah
Rights Management Copyright 2002. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright
ARK ark:/87278/s6q85czs
Setname ehsl_novel_eec
ID 1307532
Reference URL https://collections.lib.utah.edu/ark:/87278/s6q85czs
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