Walsh & Hoyt: Clinical and Visual Outcome Measures for Multiple Sclerosis Trials

With the identification of effective disease-modifying therapies for MS over the past decade, active-arm comparison studies, rather than placebo-controlled trials, are now commonplace. Such studies require more sensitive clinical outcome measures that have the capacity to demonstrate differences among active treatments. This section discusses developments in the area of clinical outcome measures for MS trials, with particular emphasis on the identification of candidate measures of visual function.