Identifier |
20140304_nanos_sciplatform2_04-1 |
Title |
Orbital Fibroblasts From Thyroid Eye Disease Patients Differ In Proliferative And Adipogenic Responses Depending On Disease Sub-type |
Creator |
Ajay E. Kuriyan; Collynn F. Woeller; Charles W. O'Loughlin; Richard P. Phipps; Steven E. Feldon |
Affiliation |
(AEK) (CFW) (SEF) University of Rochester Medical Center; (CWO) (RPP) University of Rochester Eye Institute |
Subject |
Thyroid Eye Disease; Graves' Disease; Orbital Imaging; Adipogenesis; Cyclooxygenase Inhibitors |
Description |
Thyroid Eye Disease (TED), an autoimmune process most frequently associated with Graves Disease, is the most common orbital disease. Orbital imaging can be used to classify TED patients as Type I (predominantly fat compartment enlargement) or Type II (predominantly extraocular muscle enlargement). In vitro, orbital fibroblasts (OFs) can be driven to differentiate into adipocytes or proliferate. We investigated whether Type I OFs undergo adipogenesis to a greater degree than Type II OFs, whereas Type II OFs undergo proliferation more than Type I OFs. We also studied the ability of cyclooxygenase (COX)-inhibitors to inhibit OF adipogenesis and proliferation. |
Date |
2014-03-04 |
Language |
eng |
Format |
application/pdf |
Format Creation |
Microsoft PowerPoint |
Type |
Text |
Source |
2014 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2014: Scientific Platform Presentations (Session 2) |
Collection |
Neuro-Ophthalmology Virtual Education Library: NANOS Annual Meeting Collection: https://novel.utah.edu/collection/nanos-annual-meeting-collection/ |
Publisher |
North American Neuro-Ophthalmology Society |
Holding Institution |
Spencer S. Eccles Health Sciences Library, University of Utah |
Rights Management |
Copyright 2013. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6d254cd |
Setname |
ehsl_novel_nam |
ID |
183865 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6d254cd |