| Identifier |
20070213_nanos_sciplatform_01.pdf |
| Title |
Low-Contrast Letter Acuity Loss Over Time in Multiple Sclerosis Correlates with Reductions in Retinal Nerve Fiber Layer Thickness and Macular Volume by OCT |
| Creator |
Bryn Burkholder; Heather Winslow; Ligia Nano-Schiavi; Mathew Pulicken; Peter Calabresi; Steven Galetta; Elliot Frohman; Laura Balcer |
| Affiliation |
(BB) (LN) (SG) (LB) University of Pennsylvania School of Medicine, Philadelphia, PA; (HW) (EF) University of Texas Southwestern at Dallas, Dallas, TX; (MP) (PC) The Johns Hopkins University School of Medicine, Baltimore, MD |
| Subject |
Low-contrast Letter Acuity; Optical Coherence tomography (OCT); Multiple Sclerosis (MS); Visual Function; Axonal Loss |
| Description |
Low-contrast letter acuity testing is being used with increasing frequency as an MS trial outcome. This measure demonstrated treatment effects in recent phase 3 trials of natalizumab, capturing sustained, clinically-significant visual loss. Optical coherence tomography (OCT) parameters of retinal nerve fiber layer (RNFL) thickness and macular volume are reduced in eyes of MS patients, and also demonstrate promise as MS trial endpoints. We sought to examine correlations between low-contrast letter acuity losses over time with changes in RNFL thickness and macular volume in an MS cohort. |
| Date |
2007-02-13 |
| Language |
eng |
| Format |
application/pdf |
| Type |
Text |
| Source |
2007 North American Neuro-Ophthalmology Society Annual Meeting |
| Relation is Part of |
NANOS 2007: Scientific Platform Presentations (Session II) |
| Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
| Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
| Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
| Rights Management |
Copyright 2010. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
| ARK |
ark:/87278/s6t75pvr |
| Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
| Setname |
ehsl_novel_nam |
| ID |
180936 |
| Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6t75pvr |
