Identifier |
20200310_nanos_sciplatform3_07-slides |
Title |
Proof of Concept for Levodopa Treatment in Rescuing Retinal Morphology and Visual Function in Albinism (Slides) |
Creator |
Helena Lee; Aida Sanchez-Bretano Sanchez; Jennifer Scott; Helen Griffiths; Jay Self; Andrew Lotery |
Affiliation |
(HL) (ASS) (JS) (HG) (JS) (AL) University of Southampton, Southampton, United Kingdom of Great Britain and Northern Ireland |
Subject |
Pediatric Neuro-ophthalmology; Nystagmus; Genetic Disease |
Description |
There is a paucity of treatments for oculocutaneous albinism (OCA), a condition characterised by pigment deficiency, abnormal retinal development, and significant visual disability. L-DOPA, a signalling molecule which is essential for normal retinal development, is deficient in OCA. Residual plasticity of the developing retina in young children with albinism has been demonstrated, suggesting a post-natal window for therapeutic rescue. In this study, we investigate if post-natal retinal morphology and visual function in OCA can be improved through oral Levodopa supplementation, if administered during the critical period of neuroplasticity. |
Date |
2020-03 |
Language |
eng |
Format |
application/pdf |
Format Creation |
Microsoft PowerPoint |
Type |
Text |
Source |
2020 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS Annual Meeting 2020: Scientific Platform Session III |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2020. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s6jh8w2b |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1541341 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s6jh8w2b |