Identifier |
20180306_nanos_posters_203 |
Title |
Development of Nanocarbon Antioxidants for Oxidative Stress Related Injury of the Retina |
Creator |
William Sikkema; Kimberly Mendoza; James Tour; Veeral Shah |
Affiliation |
(WS) Rice University, Baylor College of Medicine, Houston, Texas; (KM) (JT) Rice University, Houston; (VS) Baylor College of Medicine, Texas Children's Hospital, Houston, Texas |
Subject |
Optic Neuropathy; Stroke Trauma; Genetic Disease |
Description |
Optic neuropathy refers to dysfunction of the optic nerve and to the damage and death of retinal ganglion cells in particular. There; are multiple etiologies of optic neuropathy such as genetic, traumatic, inflammatory, and infectious, but oxidative stress is implicated in all of these. Nanocarbon antioxidants (NCA) have been designed to reduce oxidative stress in biological tissue at levels; where naturally derived antioxidants are ineffective. These NCAs can specifically target reactive oxygen species (ROS) more efficiently than biological antioxidant cascades, possibly because they specifically target ROS in the mitochondria and don't require cofactors or regeneration. Our central hypothesis is that optimally designed NCA will neutralize and sequester tissue damaging reactive oxygen species. We have demonstrated the safety of the nanoparticle in multiple cells lines, including ocular tissue. |
Date |
2018-03 |
Language |
eng |
Format |
application/pdf |
Type |
Text |
Source |
2018 North American Neuro-Ophthalmology Society Annual Meeting |
Relation is Part of |
NANOS 2018: Poster Presentations |
Collection |
Neuro-ophthalmology Virtual Education Library: NOVEL http://NOVEL.utah.edu |
Publisher |
Spencer S. Eccles Health Sciences Library, University of Utah |
Holding Institution |
North American Neuro-Ophthalmology Association. NANOS Executive Office 5841 Cedar Lake Road, Suite 204, Minneapolis, MN 55416 |
Rights Management |
Copyright 2018. For further information regarding the rights to this collection, please visit: https://NOVEL.utah.edu/about/copyright |
ARK |
ark:/87278/s66m774x |
Context URL |
The NANOS Annual Meeting Neuro-Ophthalmology Collection: https://novel.utah.edu/collection/NAM/toc/ |
Setname |
ehsl_novel_nam |
ID |
1310540 |
Reference URL |
https://collections.lib.utah.edu/ark:/87278/s66m774x |