Test-Retest Reliability of Hemifield, Central-Field and Full-Field Chromatic Pupillometry for Assessing the Function of Melanopsin-Containing Retinal Ganglion Cells

A sustained pupil constriction can be observed after the offset of a bright blue light stimulus. This post-illumination pupil response (PIPR) is produced by the intrinsically photosensitive melanopsin-containing retinal ganglion cells (ipRGCs), and can be measured by chromatic pupillometry. We previously described a clinically friendly chromatic pupillometry protocol that can induce PIPR with a brief blue light stimulus. The present study is to evaluate the test-retest reliability of current methods of inducing PIPR under hemifield, central-field and full-field stimulation conditions.